Product Detail
Product NameKMT5A/SETD8/Pr-SET7 Rabbit mAb
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesH4 K20 HMTase antibody
H4 K20 specific histone methyltransferase antibody
H4-K20-HMTase SETD8 antibody
Histone H4 K20 methyltransferase antibody
Histone lysine N methyltransferase H4 lysine 20 specific antibody
Histone-lysine N-methyltransferase SETD8 antibody
Lysine N-methyltransferase 5A antibody
N-lysine methyltransferase SETD8 antibody
Pr SET 7 antibody
Pr SET7 antibody
PR-Set7 antibody
PR/SET domain containing protein 07 antibody
PR/SET domain containing protein 8 antibody
PR/SET domain-containing protein 07 antibody
PR/SET07 antibody
PrSET7 antibody
SET 07 antibody
SET 8 antibody
SET domain containing (lysine methyltransferase) 8 antibody
SET domain containing 8 antibody
SET domain containing lysine methyltransferase 8 antibody
SET domain containing protein 8 antibody
SET domain-containing protein 8 antibody
SET07 antibody
SET8 antibody
SETD 8 antibody
setd8 antibody
SETD8_HUMAN antibody
Accession NoSwiss-Prot#:Q9NQR1
Uniprot
Q9NQR1
Gene ID
387893;
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
FC: 1:50-1:100
Western blot analysis of KMT5A on different lysates using anti-KMT5A antibody at 1/1,000 dilution. Positive control: Lane 1: Mouse kidney Lane 2: Mouse liver Lane 3: 293T Lane 4: 293
Flow cytometric analysis of 293T cells with KMT5A antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. All monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions , benef playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contribute to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53 / TP53 at 'Lys-382', leading to repress p53 / TP53-target genes.
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