Product Detail
Product NameKPNA2 Rabbit mAb
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms, Rt
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesIMA1_HUMAN antibody
Importin alpha 1 antibody
Importin alpha 2 antibody
Importin alpha 2 subunit antibody
Importin alpha P1 antibody
Importin subunit alpha-1 antibody
IPO A1 antibody
IPOA 1 antibody
IPOA1 antibody
Karyopherin alpha 2 antibody
Karyopherin alpha 2 RAG cohort 1 antibody
Karyopherin alpha 2 subunit antibody
Karyopherin subunit alpha-2 antibody
KPNA2 antibody
KPNA2 protein antibody
Pendulin antibody
QIP 2 antibody
QIP2 antibody
RAG cohort 1 antibody
RAG cohort protein 1 antibody
RCH 1 antibody
RCH1 antibody
SRP 1 antibody
SRP1 alpha antibody
SRP1 antibody
SRP1-alpha antibody
SRP1alpha antibody
Accession NoSwiss-Prot#:P52292
Uniprot
P52292
Gene ID
3838;
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
FC: 1:50-1:100
Western blot analysis of KPNA2 on different cell lysates using anti-KPNA2 antibody at 1/1,000 dilution. Postive control: Lane 1: Hela Lane 2: 293T Lane 3: HepG2 Lane 4: NIH-3T3 Lane 5: PC-12
Flow cytometric analysis of 293T cells with KPNA2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
If you have published an article using product 49651, please notify us so that we can cite your literature.
Yes
