Product Detail
Product NameTMEM173 Rabbit mAb
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC, ICC/IF
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other Namesendoplasmic reticulum IFN stimulator antibody
Endoplasmic reticulum interferon stimulator antibody
ERIS antibody
FLJ38577 antibody
hMITA antibody
hSTING antibody
Mediator of IRF3 activation antibody
MITA antibody
Mitochondrial mediator of IRF3 activation antibody
MPYS antibody
N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody
NET23 antibody
Stimulator of interferon genes antibody
Stimulator of interferon genes protein antibody
STING antibody
TM173_HUMAN antibody
Tmem173 antibody
Transmembrane protein 173 antibody
Accession NoSwiss-Prot#:Q86WV6
Uniprot
Q86WV6
Gene ID
340061;
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
ICC: 1:10-1:50
FC: 1:50-1:100
Western blot analysis of TMEM173 on U937 (1) and 293 (2) cell lysate using anti-TMEM173 antibody at 1/1,000 dilution.
Flow cytometric analysis of THP-1 cells with TMEM173 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
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