Product Detail
Product NameMVP Rabbit mAb
Clone No.JM74-73
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms, Rt
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesLRP antibody
Lung resistance related protein antibody
Lung resistance-related protein antibody
Major vault protein antibody
Major vault protein, rat, homolog of antibody
MVP antibody
MVP_HUMAN antibody
testicular secretory protein Li 30 antibody
VAULT 1 antibody
VAULT1 antibody
Accession NoSwiss-Prot#:Q14764
Uniprot
Q14764
Gene ID
9961;
Calculated MW99 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
Major vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of MVP is TATA-less; contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. MVP has two alternative splice variants, which differ from each other within the 5'-leader. The long-MVP isoform is ubiquitously expressed and represents an almost constant portion of the total MVP mRNA in many different normal tissues. MVP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, MVP protein mediates drug resistance, perhaps via a transport process.
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