Product Detail
Product NameALIX Rabbit mAb
Clone No.JM85-31
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, FC
Species ReactivityHu, Ms, Rt
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesAIP1 antibody
ALG 2 interacting protein 1 antibody
ALG-2-interacting protein 1 antibody
ALG2 interacting protein X antibody
Alix antibody
Apoptosis linked gene 2 interacting protein X antibody
Dopamine receptor interacting protein 4 antibody
DRIP4 antibody
Hp95 antibody
KIAA1375 antibody
MGC17003 antibody
PDC6I_HUMAN antibody
PDCD6 interacting protein antibody
PDCD6-interacting protein antibody
PDCD6IP antibody
Programmed cell death 6 interacting protein antibody
Programmed cell death 6-interacting protein antibody
Accession NoSwiss-Prot#:Q8WUM4
Uniprot
Q8WUM4
Gene ID
10015;
Calculated MW96 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
FC: 1:50-1:100
ALG-2-interacting protein (Alix), also designated programmed cell death 6-interacting protein (PDCD6-interacting protein), is a cytoplasmic protein. Alix interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. Additionally, Alix interacts with the endosomal sorting complexes required for transport (ESCRT) proteins (Tsg101 and CHMP4) and can associate with HIV-1. The endophilins (SH3P4, SH3P8 and SH3P13), enzymes that change curvature of the membrane that are required for early and late steps of coated vesicle formation, also bind to Alix. Alix is involved in the concentration and sorting of cargo proteins of the multivesicular body for incorporation into vesicles.
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