Product Detail
Product NameDNA Ligase IV Rabbit mAb
Clone No.JM64-32
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, ICC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesDNA ligase IV ATP dependent antibody
DNA joinase antibody
DNA ligase 4 antibody
DNA ligase IV antibody
DNA repair enzyme antibody
DNLI4_HUMAN antibody
LIG 4 antibody
LIG4 antibody
LIG4S antibody
Ligase IV antibody
Ligase IV DNA ATP dependent antibody
Polydeoxyribonucleotide synthase [ATP] 4 antibody
Polydeoxyribonucleotide synthase 4 antibody
Polydeoxyribonucleotide synthase antibody
Polynucleotide ligase antibody
Sealase antibody
Accession NoSwiss-Prot#:P49917
Uniprot
P49917
Gene ID
3981;
Calculated MW104 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IHC: 1:50-1:200
ICC: 1:10-1:50
The X-ray repair cross-complementing protein XRCC4 and DNA Ligase IV are essential for repairing double-strand breaks in DNA. These stories form a critical complex composed of two molecules of each protein that preferentially bind DNA with nicks or broken ends. As an obligatory accessory molecule, XRCC4 binds to DNA Ligase IV and enhances its joining activity. The XRCC4 / DNA Ligase IV complex is also involved in V (D) J recombination. V (D) (in) a pair of high incidence of apoptosis in the development nervous system and a block in B and T cell maturation.
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