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Location： Home > Recombinant Rabbit Monoclonal Antibodies > Epac1 Rabbit mAb

Epac1 Rabbit mAb#49669

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Product Detail

Product NameEpac1 Rabbit mAb

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC, IP, ICC/IF

Species ReactivityHu, Ms

Immunogen DescRecombinant protein

ConjugateUnconjugated

Other Namesbcm910 antibody
CAMP GEFI antibody
cAMP regulated guanine nucleotide exchange factor I antibody
CAMPGEFI antibody
CGEF 1 antibody
CGEF1 antibody
EPA1 antibody
Epac 1 antibody
EPAC antibody
EPAC1 antibody
Exchange factor directly activated by cAMP 1 antibody
Exchange protein directly activated by cAMP 1 antibody
MGC21410 antibody
RAP guanine nucleotide exchange factor antibody
Rap guanine nucleotide exchange factor (GEF) 3 antibody
RAP guanine nucleotide exchange factor 3 antibody
Rap1 guanine nucleotide exchange factor directly activated by cAMP antibody
RAPGEF3 antibody

Accession NoSwiss-Prot#:O95398

Uniprot O95398

Gene ID 10411;

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200
ICC/IF: 1:10-1:50
IP: 1:10-1:50
Western blot analysis of Epac1 on mouse kidney tissue lysate using anti-Epac1 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-Epac1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti-Epac1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Epac1 antibody. Counter stained with hematoxylin.
3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac (Epac1, cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the Ras family GTPases Rap 1 and Rap 2 by promoting GTP binding in a cAMP-dependent manner. Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission. The human Epac gene maps to chromosome 12q13.11 with transcript being abundant in the kidney and heart. In situ hybridization indicates expression of Epac in adult rat brain and selective expression in neonatal brain, including septum and thalamus.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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