Product Detail
Product NamePlexin A1 Rabbit mAb
Clone No.JU50-37
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB,ICC,FC
Species ReactivityHu, Ms, Rt
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesNOV antibody
NOV/plexin A1 protein antibody
NOVP antibody
Plexin-A1 antibody
Plexin1 antibody
PlexinA1 antibody
PLXA1_HUMAN antibody
PLXN1 antibody
Plxna1 antibody
PLXNA1 protein antibody
Semaphorin receptor NOV antibody
Accession NoSwiss-Prot#:Q9UIW2
Uniprot
Q9UIW2
Gene ID
5361;
Calculated MW211 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
ICC: 1:50-1:200
FC: 1:50-1:100
ICC staining Plexin A1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of LOVO cells with Plexin A1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
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