Product Detail
Product NameTRAF6 Rabbit mAb
Clone No.S09-3F4
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
IsotypeRabbit IgG
PurificationAffinity Purified
ApplicationsWB
Species ReactivityHuman,Mouse,Rat
Immunogen DescA synthetic peptide of human TRAF6
ConjugateUnconjugated
Other NamesRNF85; MGC:3310
Accession NoSwiss-Prot:Q9Y4K3
GeneID:7189
Uniprot
Q9Y4K3
Gene ID
7189
Calculated MWCalculated MW: 60 kDa; Observed MW: 60 kDa
Concentration0.3 mg/ml
Formulation50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
StorageStore at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Application Details
WB: 1/1000-1/5000;
Western blot detection of TRAF6 in 293 cell lysates using TRAF6 Rabbit mAb(1:1000 diluted).Predicted band size:60KDa.Observed band size:60KDa.
Swiss-Prot Acc.Q9Y4K3.E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
If you have published an article using product 52627, please notify us so that we can cite your literature.
et al,Classical prescription Daqinjiao decoction inhibit cerebral ischemia/reperfusion induced necroptosis and ferroptosis through multiple mechanisms.
, (2025),
PMID:
39736347
Yes
