Product Detail
Product NameE-Cadherin Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IHC,IF
Species ReactivityHuman,Mouse,Rat
Immunogen DescA synthetic peptide of human E-Cadherin (NP_004351.1).
ConjugateUnconjugated
Other NamesArc-1;CD324;CDHE;ECAD;LCAM;UVO;CDH1;E-Cadherin
Accession NoUniprot:P12830
GeneID:999
Uniprot
P12830
Gene ID
999
Calculated MW90kDa/97kDa
Sdspage MW80KDa
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:1000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using E-Cadherin antibody.
Immunohistochemistry of paraffin-embedded Rat kidney using E-Cadherin antibody.
Immunofluorescence analysis of A431 cells using E-Cadherin Rabbit pAb.
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
If you have published an article using product 53252, please notify us so that we can cite your literature.
et al,Overexpression of Epithelial Splicing Regulatory Protein 1 in Metastatic Lesions of Serous Ovarian Carcinoma Correlates with Poor Patient Prognosis. In Cancer Biother Radiopharm on 2021 Sep 8 by Xinxin Lu, Runzhou Li, et al..PMID:34495766
, (2021),
PMID:
34495766
et al,Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IκB-α.In Front Immunol. 2022 Jan 24 by Zeping Gui , Chuanjian Suo,et al.PMID: 35140705
, (2022),
PMID:
35140705
et al,Overexpression of Epithelial Splicing Regulatory Protein 1 in Metastatic Lesions of Serous Ovarian Carcinoma Correlates with Poor Patient Prognosis. In Cancer Biother Radiopharm on 2022 Nov by Xinxin Lu, Runzhou Li, et al..PMID:34495766
, (2022),
PMID:
34495766
et al,Stevioside inhibits lipopolysaccharide-induced epithelial-to-mesenchymal transition of NRK-52E cells by PPARγ activation. In Immunopharmacol Immunotoxicol
on 2022 Apr by Wei Shen, Hui Huang， et al..PMID:35139741
, (2022),
PMID:
35139741
Yes
