Product Detail
                                
                                                                        Product NamePSME2 Rabbit Polyclonal Antibody
                                                                                 Host SpeciesRabbit
                                         ClonalityPolyclonal
                                        IsotypeIgG
                                        PurificationAffinity purification
                                        ApplicationsWB
                                        Species ReactivityHuman,Mouse
                                                                                                                         Immunogen DescRecombinant fusion protein of human PSME2 (NP_002809.2).
                                                                                 ConjugateUnconjugated
                                                                                 Other NamesPSME2;PA28B;PA28beta;REGbeta
                                        Accession NoUniprot:Q9UL46
GeneID:5721
                                        Uniprot
                                        Q9UL46
                                        
                                        Gene ID
                                        5721
                                        
                                        Calculated MW27kDa
                                        Sdspage MW27kDa
                                                                                 FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
                                        StorageStore at -20˚C. Avoid freeze / thaw cycles.
                                                                                                                                                         
                                Application Details
                                WB	1:500 - 1:2000
                             
                            
                                                                
                                    
                                    Western blot analysis of extracts of various cell lines, using PSME2 antibody.
                                 
                                                             
                            
                                The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.  An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. 
                            
                            
                                If you have published an article using product 53683, please notify us so that we can cite your literature.
                                                                                                    
                                      et al,Machine learning-based characterization of PANoptosis-related biomarkers and immune infiltration in ulcerative colitis: A comprehensive bioinformatics analysis and experimental validation.
 ,  (2025),
PMID:
                                    39986196