Product Detail
Product NameSLAMF7 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB
Species ReactivityHuman,Mouse
Immunogen DescRecombinant fusion protein of human SLAMF7 (NP_067004.3).
ConjugateUnconjugated
Other NamesSLAMF7;19A;CD319;CRACC;CS1
Accession NoUniprot:Q9NQ25
GeneID:57823
Uniprot
Q9NQ25
Gene ID
57823
Calculated MW17kDa/21kDa/22kDa/25kDa/32kDa/37kDa
Sdspage MW25-70KDa
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using SLAMF7 antibody.
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed on the surface of NK cells, CD8+ T cells, activated B cells, and mature dendritic cells but not in promyelocytic, B-cell lines, or T-cell lines. In human NK cells, activated SLAMF7 transmits signals following association with the adaptor protein EAT-2 . In the absence of EAT-2, SLAMF7 potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
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