Product Detail
Product NameGCG Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IHC,IF
Species ReactivityHuman,Mouse,Rat
Immunogen DescRecombinant fusion protein of human GCG (NP_002045.1).
ConjugateUnconjugated
Other NamesGCG;GLP-1;GLP1;GLP2;GRPP;glucagon
Accession NoSwiss Prot:P01275
Gene ID:2641
Uniprot
P01275
Gene ID
2641
Calculated MW20kDa
Sdspage MW21kDa
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using GCG antibody.
Immunohistochemistry of paraffin-embedded mouse pancreatic islet using GCG antibody.
Immunofluorescence analysis of rat pancreas using GCG antibody.
Immunofluorescence analysis of mouse pancreas using GCG antibody.
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
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