Product Detail
Product NameTERT Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IHC
Species ReactivityHuman,Mouse
Immunogen DescA synthetic peptide of human TERT (NP_937983.2).
ConjugateUnconjugated
Other NamesTERT;CMM9;DKCA2;DKCB4;EST2;PFBMFT1;TCS1;TP2;TRT;hEST2;hTRT
Accession NoSwiss Prot:O14746
GeneID:7015
Uniprot
O14746
Calculated MW88kDa/90kDa/120kDa/126kDa
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:2000 - 1:5000
IHC 1:50 - 1:200
Immunohistochemistry of paraffin-embedded human breast cancer using TERT at dilution of 1:100 (40x lens).
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
If you have published an article using product 54247, please notify us so that we can cite your literature.
et al,CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma.
, (2025),
PMID:
40044674
Yes
