Product Detail
                                
                                                                        Product NameKIAA0196 Rabbit Polyclonal Antibody
                                                                                 Host SpeciesRabbit
                                         ClonalityPolyclonal
                                        IsotypeIgG
                                        PurificationAffinity purification
                                        ApplicationsWB,IHC
                                        Species ReactivityMouse,Rat
                                                                                                                         Immunogen DescRecombinant fusion protein of human KIAA0196 (NP_055661.3).
                                                                                 ConjugateUnconjugated
                                                                                 Other NamesRTSC; SPG8; RTSC1; KIAA0196
                                        Accession NoSwiss Prot:Q12768
Gene ID:9897
                                        Uniprot
                                        Q12768
                                        
                                        Gene ID
                                        9897
                                        
                                        Calculated MW_
                                        Sdspage MW134KDa
                                                                                 FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
                                        StorageStore at -20˚C. Avoid freeze / thaw cycles.
                                                                                                                                                         
                                Application Details
                                WB	1:2000 - 1:5000
IHC	1:50 - 1:200
                             
                            
                                                                
                                    
                                    Western blot analysis of extracts of Mouse thymus, using KIAA0196 antibody.
                                 
                                                                
                                    
                                    Immunohistochemistry of paraffin-embedded rat brain using KIAA0196 Rabbit pAb.
                                 
                                                                
                                    
                                    Immunohistochemistry of paraffin-embedded mouse spinal cord using KIAA0196 Rabbit pAb.
                                 
                                                             
                            
                                This gene encodes a 134 kDa protein named strumpellin that is predicted to have multiple transmembrane domains and a spectrin-repeat-containing domain. This ubiquitously expressed gene has its highest expression in skeletal muscle. The protein is named for Strumpell disease; a form of hereditary spastic paraplegia (HSP). Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive, lower extremity spasticity caused by axonal degeneration in the terminal portions of the longest descending and ascending corticospinal tracts. More than 30 loci (SPG1-33) have been implicated in hereditary spastic paraplegia diseases.
                            
                            
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