Product Detail
Product NameAGO1 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB
Species ReactivityHuman
Immunogen DescA synthetic peptide of human AGO1 (NP_036331.1).
ConjugateUnconjugated
Other NamesAGO1;EIF2C;EIF2C1;GERP95;Q99;hAgo1
Accession NoUniprot:Q9UL18
GeneID:26523
Uniprot
Q9UL18
Gene ID
26523
Calculated MW97kDa
Sdspage MW97kDa
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:1000
Western blot analysis of extracts of various cell lines, using AGO1 antibody.
This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon.
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2-3 weeks
