Product Detail
Product NameEIF4G1 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB
Species ReactivityHuman
Immunogen DescA synthetic peptide of human EIF4G1 (NP_886553.3).
ConjugateUnconjugated
Other NamesEIF4G1;EIF-4G1;EIF4F;EIF4G;EIF4GI;P220;PARK18
Accession NoUniprot:Q04637
GeneID:1981
Uniprot
Q04637
Gene ID
1981
Calculated MW154kDa/158kDa/166kDa/171kDa/175kDa/176kDa
Sdspage MW220KDa
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
Western blot analysis of extracts of HeLa cells, using EIF4G1 antibody.
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
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