Product Detail
Product NameDNM2 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IF
Species ReactivityMouse,Rat
Immunogen DescRecombinant fusion protein of human DNM2 (NP_004936.2).
ConjugateUnconjugated
Other NamesDNM2;CMT2M;CMTDI1;CMTDIB;DI-CMTB;DYN2;DYNII;LCCS5;dynamin-2
Accession NoSwiss Prot:P50570
GeneID:1785
Uniprot
P50570
Calculated MW97kDa/98kDa
Sdspage MW125kDa
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using DNM2 at 1:1000 dilution.
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
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