Product Detail
Product NameARHGEF11 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IHC
Species ReactivityHuman,Mouse
Immunogen DescA synthetic peptide of human ARHGEF11
ConjugateUnconjugated
Other NamesARHGEF11;GTRAP48;PDZ-RHOGEF
Accession NoSwiss Prot:O15085
GeneID:9826
Uniprot
O15085
Calculated MW167kDa/172kDa
Sdspage MW168kDa
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:100
Western blot analysis of extracts of mouse brain, using ARHGEF11 at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded human prostate cancer using ARHGEF11 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using ARHGEF11 (40x lens).
Immunohistochemistry of paraffin-embedded human colon using ARHGEF11 (40x lens).
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
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