Product Detail
Product NameARHGEF3 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB
Species ReactivityHuman,Mouse
Immunogen DescRecombinant fusion protein of human ARHGEF3 (NP_062455.1).
ConjugateUnconjugated
Other NamesARHGEF3;GEF3;STA3;XPLN
Accession NoUniprot:Q9NR81
GeneID:50650
Uniprot
Q9NR81
Gene ID
50650
Calculated MW36kDa/59kDa/60kDa/63kDa
Sdspage MW60kDa
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using ARHGEF3 antibody.
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
If you have published an article using product 55528, please notify us so that we can cite your literature.
Yes
