Product Detail
Product NamePRDM2 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IHC
Species ReactivityRat
Immunogen DescRecombinant fusion protein of human PRDM2 (NP_036363.2).
ConjugateUnconjugated
Other NamesPRDM2;HUMHOXY1;KMT8;KMT8A;MTB-ZF;RIZ;RIZ1;RIZ2
Accession NoSwiss Prot:Q13029
GeneID:7799
Uniprot
Q13029
Calculated MW25kDa/162kDa/166kDa/184kDa/188kDa
Sdspage MW250kDa
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of rat heart, using PRDM2 at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded rat lung using PRDM2 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat liver using PRDM2 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat testis using PRDM2 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat brain using PRDM2 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat kidney using PRDM2 at dilution of 1:100 (40x lens).
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
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