Product Detail
Product NameVPS33B Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IF
Species ReactivityHuman,Mouse
Immunogen DescRecombinant fusion protein of human VPS33B (NP_061138.3).
ConjugateUnconjugated
Other NamesVPS33B
Accession NoSwiss Prot:Q9H267
GeneID:26276
Uniprot
Q9H267
Calculated MW60kDa/70kDa
Sdspage MW62kDa
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:1000 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using VPS33B at 1:1000 dilution.
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants.
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