Product Detail
Product NamePSPC1 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IHC
Species ReactivityHuman,Mouse,Rat
Immunogen DescRecombinant fusion protein of human PSPC1 (NP_001035879.1).
ConjugateUnconjugated
Other NamesPSPC1;PSP1
Accession NoSwiss Prot:Q8WXF1
GeneID:55269
Uniprot
Q8WXF1
Calculated MW45kDa/58kDa
Sdspage MW65kDa
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:2000 - 1:5000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using PSPC1 at 1:3000 dilution.
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.
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