Product Detail
Product NameDSG1 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IF
Species ReactivityHuman,Rat
Immunogen DescRecombinant fusion protein of human DSG1 (NP_001933.2).
ConjugateUnconjugated
Other NamesDSG1;CDHF4;DG1;DSG;EPKHE;EPKHIA;PPKS1;SPPK1
Accession NoUniprot:Q02413
GeneID:1828
Uniprot
Q02413
Gene ID
1828
Calculated MW42kDa/113kDa
Sdspage MW150kDa
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IF 1:50 - 1:100
Western blot analysis of extracts of various cell lines, using DSG1 antibody.
Immunofluorescence analysis of rat skin using DSG1 antibody.
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
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