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Location： Home > Mouse Monoclonal Antibodies > Her-2 mouse mAb(ABT008)

Her-2 mouse mAb(ABT008)#57168

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Product Detail

Product NameHer-2 mouse mAb(ABT008)

Host SpeciesMouse

ClonalityMonoclonal

IsotypeIgG2a, Kappa

PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

ApplicationsIHC;IF;WB

Species ReactivityHuman

SpecificityThe antibody can specifically recognize human Her-2 protein.

Immunogen DescSynthesized peptide derived from human Her-2

Target NameERBB2 HER2 MLN19 NEU NGL

ConjugateUnconjugated

Uniprot P04626

Gene ID 2064

Calculated MW137kd

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

StorageStore at -20℃/1 year

Application Details

 IHC 1:100-500, IF 1:100-500, WB 1:500-2000

Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-Her-2(ABT088) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: MCF7 Predicted band size: 137kDa Observed band size: 200kDa
Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-Her-2(ABT088) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: SK-BR-3 Predicted band size: 137kDa Observed band size: 200kDa
Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-Her-2(ABT008) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: T47D Predicted band size: 137kDa Observed band size: 180kDa
Human breast carcinoma tissue was stained with Anti-Her-2 (ABT008) Antibody
Human breast carcinoma tissue was stained with Anti-Her-2 (ABT008) Antibody
Human metastatic hepatocellular carcinoma of the breast tissue was stained with Anti-Her-2 (ABT008) Antibody

 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. 

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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