Product Detail
Product NameSNAP25 Rabbit mAb
Host SpeciesRabbit
ClonalityMonoclonal
IsotypeRabbit IgG
PurificationAffinity-chromatography
ApplicationsWB ICC/IF IP
Species ReactivityHuman Mouse Rat
SpecificitySNAP25 Antibody detects endogenous levels of total SNAP25
Immunogen DescA synthesized peptide derived from human SNAP25
Other NamesSynaptosomal-associated protein 25; SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP;
Accession NoUniprot:P60880
Uniprot
P60880
FormulationRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at +4˚C short term. Store at -20˚C long term. Avoid freeze / thaw cycle.
Application Details
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50
Western blot analysis of SNAP25 expression in SH-SY5Y cell lysate.
SNAP25 forms a core complex with the SNARE proteins syntaxin and synaptobrevin to mediate synaptic vesicle fusion with the plasma membrane during Ca2+-dependent exocytosis. This complex is responsible for exocytosis of the neurotransmitter γ-aminobutyric acid (GABA). Neurotransmitter release is inhibited by proteolysis of SNAP25 by botulinum toxins A and E. SNAP25 plays a secondary role as a Q-SNARE involved in endosome fusion; the protein is associated with genetic susceptibility to attention-deficit hyperactivity disorder (ADHD).
If you have published an article using product 59465, please notify us so that we can cite your literature.
Yes
