Product Detail
Product NameCox2 Rabbit mAb
Host SpeciesRabbit
ClonalityMonoclonal
IsotypeRabbit IgG
PurificationAffinity-chromatography
ApplicationsWB IHC IP
Species ReactivityHuman Mouse
SpecificityCox2 Antibody detects endogenous levels of total Cox2
Immunogen DescA synthesized peptide derived from human Cox2
Other NamesCOX2; COX-2; Cyclooxygenase 2; PGH2; PGHS2; PHS2; TIS10; PTGS2;
Accession NoUniprot:P35354
Uniprot
P35354
FormulationRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at +4˚C short term. Store at -20˚C long term. Avoid freeze / thaw cycle.
Application Details
WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50
Western blot analysis of Cox2 expression in A549 cell lysate.
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
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