Product Detail
Product NameNMDAR2A (phospho-Tyr1325) antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsELISA
Species ReactivityHuman, Mouse, Rat
SpecificityThis antibody detects endogenous levels of human NMDAR2A when phosphorylated at Tyr1325.
Immunogen TypePeptide
Immunogen Descpeptide derived from NMDAR2A, corresponding to amino acid residues around phosphorylated Tyr1325.
Target NameNMDAR2A
Uniprot
Q12879
Gene ID
2903
Calculated MW165kDa
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
StorageStore at +4˚C for short term. Store at -20˚C for long term. Avoid freeze/thaw cycle.
Application Details
ELISA 1:20000-1:40000
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
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