Product Detail
Product NameHIV1 gp120 antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity purified by Protein A.
ApplicationsELISA
Species ReactivityHIV-1
Immunogen TypePeptide
Immunogen Descpeptide derived from HIV1 Surface protein gp120: 301-334/857
Target NameHIV1 gp120
Uniprot
P05877
Calculated MW53/91 kDa
Concentration1mg/ml
FormulationLiquid in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageStore at +4˚C for short term. Store at -20˚C for long term. Avoid freeze/thaw cycle.
Application Details
ELISA 1:5000-10000
The attachment of enveloped viruses to cells and the fusion of viral and cellular membranes are critical early events in the HIV viral infection. This process is mediated by envelope glycoproteins (gp) on the surface of the virus. The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein, gp160, is proteolytically cleaved into gp120 and gp41, which remain noncovalently associated with one another. gp120 is one of the proteins that forms the envelope of HIV. gp120 projects from the surface of HIV and binds to the CD4 molecule on helper T cells. gp120 has been a logical experimental HIV vaccine because the outer envelope is the first part of the virus that encounters antibody. gp41 is embedded in the outer envelope of HIV that anchors gp120. gp41 also plays a key role in HIV's infection of CD4+ T cells by facilitating the fusion of the viral and cell membranes. The nomenclature of the gp proteins describes their respective molecular masses (e.g., gp160, gp120, gp41).
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