Product Detail
Product NameRecombinant Human Cyclin-dependent kinase inhibitor 1(CDKN1A)
Host SpeciesE.coli
PurificationGreater than 90% as determined by SDS-PAGE.
Immunogen DescExpression Region:2-164aa
Sequence Info:Full Length
Other NamesCDK-interacting protein 1Melanoma differentiation-associated protein 6 ;MDA-6p21
Accession NoP38936
Uniprot
P38936
Gene ID
1026;
Calculated MW45 kDa
FormulationTris-based buffer50% glycerol
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Tag InfoN-terminal GST-tagged
Application Details
May be the important intermediate by which p53,TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assbly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
If you have published an article using product AP70153, please notify us so that we can cite your literature.
8-15 business day
