Product Detail
Product NameRecombinant Human Interferon-induced protein with tetratricopeptide repeats 3(IFIT3)
Host SpeciesE.coli
PurificationGreater than 90% as determined by SDS-PAGE.
Immunogen DescExpression Region:1-490aa
Sequence Info:Full Length
Other NamesCIG49ISG-60Interferon-induced 60KDA protein ;IFI-60KInterferon-induced protein with tetratricopeptide repeats 4 ;IFIT-4Retinoic acid-induced gene G protein ;P60 ;RIG-G
Accession NoO14879
Uniprot
O14879
Gene ID
3437;
Calculated MW72 kDa
FormulationTris-based buffer50% glycerol
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Tag InfoN-terminal 6xHis-SUMO-tagged
Application Details
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A,p21 and CDKN1B,p27. Normally, CDKN1B,p27 turnover is regulated by COPS5, which binds CDKN1B,p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B,p27 protein levels. Upregulates CDKN1A,p21 by downregulating MYC, a repressor of CDKN1A,p21. Can negatively regulate the apoptotic effects of IFIT2.
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