Product Detail
Product NameRecombinant Rat Integrin beta-1(Itgb1) ,partial
Host SpeciesE.coli
PurificationGreater than 90% as determined by SDS-PAGE.
Immunogen DescExpression Region:21-729aa
Sequence Info:Extracellular Domain
Other NamesBeta oligodendroglia ;Beta OLFibronectin receptor subunit betaVLA-4 subunit beta; CD29
Accession NoP49134
Uniprot
P49134
Gene ID
24511;
Calculated MW94.4 kDa
FormulationTris-based buffer50% glycerol
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Tag InfoN-terminal 6xHis-SUMO-tagged
Application Details
Integrins alpha-1,beta-1, alpha-2,beta-1, alpha-10,beta-1 and alpha-11,beta-1 are receptors for collagen. Integrins alpha-1,beta-1 and alpha-2,beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2,beta-1, alpha-3,beta-1, alpha-4,beta-1, alpha-5,beta-1, alpha-8,beta-1, alpha-10,beta-1, alpha-11,beta-1 and alpha-V,beta-1 are receptors for fibronectin. Alpha-4,beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5,beta-1 is a receptor for fibrinogen. Integrin alpha-1,beta-1, alpha-2,beta-1, alpha-6,beta-1 and alpha-7,beta-1 are receptors for lamimin. Integrin alpha-4,beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9,beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3,beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3,beta-1 provides a docking site for FAP (seprase) at invadopodia plasma mbranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3,beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V,beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7,beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assbly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
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