Product Detail
Product NameRecombinant Human Nephrocystin-1(NPHP1),partial
Host SpeciesE.coli
PurificationGreater than 90% as determined by SDS-PAGE.
Immunogen DescExpression Region:1-109aa
Sequence Info:Partial
Other NamesJuvenile nephronophthisis 1 protein
Accession NoO15259
Uniprot
O15259
Gene ID
4867;
Calculated MW39.7 kDa
FormulationTris-based buffer50% glycerol
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Tag InfoN-terminal GST-tagged
Application Details
Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L,NPHP8 . Does not se to be strictly required for ciliogenesis . Ses to help to recruit PTK2B,PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B,PYK2 and PTK2B,PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assbly. Required for normal retina development. In connecting photoreceptor cilia influences the movent of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis .
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8-15 business day
