Product Detail
Product NameRecombinant Echis carinatus Disintegrin EC3B
Host SpeciesE.coli
PurificationGreater than 90% as determined by SDS-PAGE.
Immunogen DescExpression Region:1-67aa
Sequence Info:Full Length
Accession NoP81631
Uniprot
P81631
Calculated MW23.4 kDa
FormulationTris-based buffer50% glycerol
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Tag InfoN-terminal 6xHis-SUMO-tagged
Application Details
Inhibits adhesion of cells expressing alpha-4,beta-1 (ITGA4,ITGB1) and alpha-4,beta-7 (ITGA4,ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1). It is also a weaker inhibitor of alpha-5,beta-1 (ITGA5,ITGB1) and alpha-2b,beta-3 (ITGA2B,ITGB3) integrins. The inhibitory activity of EC3 towards alpha-4 integrins is associated with the MLD sequence of EC3B subunit. The ability of EC3 to inhibit ITGA5,ITGB1 resides in both subunits A and B.
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15-25 business day
