Product Detail
Product NameFas Ligand Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
Applications Flow-Cyt ICC IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 170-220 281 derived from human Fas Ligand
Target NameFas Ligand
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesAPTL; FASL; CD178; CD95L; ALPS1B; CD95-L; TNFSF6; APT1LG1; Tumor necrosis factor ligand superfamily member 6; Apoptosis antigen ligand; CD95 ligand; Fas antigen ligand; Fas ligand; FASLG
Accession NoSwiss-Prot#P48023
NCBI Gene ID356
Uniprot
P48023
Gene ID
356;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
Cytokine that binds to TNFRSF6 FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6 FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B DcR3 modulates its effects. The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.
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15 business days.
