Product Detail
Product NameIGF1R Antibody PE Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFCM
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 260-290 1367 derived from human IGF-1R alpha chain
Target NameIGF1R
ConjugatePE
Excitation Emission480,565nm 578nm
Other NamesIGFR; CD221; IGFIR; JTK13; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; IGF1R
Accession NoSwiss-Prot#P08069
NCBI Gene ID3480
Uniprot
P08069
Gene ID
3480;
Concentration1mg ml
Formulation10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Store at 4C for 12 months.
Application Details
FCM: 1:20-100
When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
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