Product Detail
                                
                                                                        Product NameTERT Antibody FITC Conjugated
                                                                                 Host SpeciesRabbit
                                         ClonalityPolyclonal
                                        IsotypeIgG
                                        PurificationPurified by Protein A.
                                        Applications Flow-Cyt IF
                                        Species ReactivityHu Ms Rt 
                                                                                                                         Immunogen DescKLH conjugated synthetic peptide aa 635-680 1132 derived from human TERT??
                                         Target NameTERT
                                         ConjugateFITC
                                         Excitation Emission494nm 518nm
                                         Other NamesTP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1; Telomerase reverse transcriptase; Telomerase catalytic subunit; Telomerase-associated protein 2; TERT
                                        Accession NoSwiss-Prot#O14746
NCBI Gene ID7015
                                        Uniprot
                                        O14746
                                        
                                        Gene ID
                                        7015;
                                        
                                                                                                                        Concentration1mg ml
                                         Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
                                        StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
                                                                                                                                                         
                                Application Details
                                Flow-Cyt=1:50-200 IF=1:50-200 
                             
                            
                                                            
                            
                                Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
                            
                            
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