Product Detail
Product NameC5a anaphylatoxin Antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsWB IHC-P IHC-F
Species ReactivityHu Ms
Immunogen DescKLH conjugated synthetic peptide aa 700-755 1680 derived from mouse C5a (725-770aa)
Target NameC5a anaphylatoxin
ConjugateHRP
Excitation EmissionN A
Other NamesC5; He; C5a; Complement C5; Hemolytic complement; Hc
Accession NoSwiss-Prot#P06684
NCBI Gene ID15139
Uniprot
P06684
Gene ID
15139;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
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15 business days.
