Product Detail
Product NameIntegrin beta 3 Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt IF
Species ReactivityHu Ms
Immunogen DescKLH conjugated synthetic peptide aa 27-77 788 derived from human Integrin beta 3
Target NameIntegrin beta 3
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesGT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; Integrin beta-3; Platelet membrane glycoprotein IIIa; ITGB3
Accession NoSwiss-Prot#P05106
NCBI Gene ID3690
Uniprot
P05106
Gene ID
3690;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=1:50-200 IF=1:50-200
Integrin alpha-V beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb beta-3 and alpha-V beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb beta-3 brings about platelet platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
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