Product Detail
Product NameIntegrin beta 1 Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 10-60 798 derived from human Integrin beta 1
Target NameIntegrin beta 1
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesCD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA; Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; VLA-4 subunit beta; ITGB1
Accession NoSwiss-Prot#P05556
NCBI Gene ID3688
Uniprot
P05556
Gene ID
3688;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=1:50-200 IF=1:50-200
Integrins alpha-1 beta-1, alpha-2 beta-1, alpha-10 beta-1 and alpha-11 beta-1 are receptors for collagen. Integrins alpha-1 beta-1 and alpha-2 beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2 beta-1, alpha-3 beta-1, alpha-4 beta-1, alpha-5 beta-1, alpha-8 beta-1, alpha-10 beta-1, alpha-11 beta-1 and alpha-V beta-1 are receptors for fibronectin. Alpha-4 beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5 beta-1 is a receptor for fibrinogen. Integrin alpha-1 beta-1, alpha-2 beta-1, alpha-6 beta-1 and alpha-7 beta-1 are receptors for lamimin. Integrin alpha-4 beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9 beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3 beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3 beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
If you have published an article using product C00295F, please notify us so that we can cite your literature.
15 business days.
