Product Detail
Product NameSCF Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 160-210 273 derived from human SCF
Target NameSCF
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesSF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; Kit ligand; Mast cell growth factor; Stem cell factor; c-Kit ligand; KITLG
Accession NoSwiss-Prot#P21583
NCBI Gene ID4254
Uniprot
P21583
Gene ID
4254;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=3ug/Test IF=1:50-200
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1 ERK2 and or MAPK3 ERK1. KITLG SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG SCF acts synergistically with other cytokines, probably interleukins.
If you have published an article using product C00326F, please notify us so that we can cite your literature.
15 business days.
