Product Detail
Product NameIGF1R Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 1300-1367 1367 derived from human IGF-1 receptor beta chain
Target NameIGF1R
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesIGFR; CD221; IGFIR; JTK13; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; IGF1R
Accession NoSwiss-Prot#P08069
NCBI Gene ID3480
Uniprot
P08069
Gene ID
3480;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=1:50-200 IF=1:50-200
When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
If you have published an article using product C00395F, please notify us so that we can cite your literature.
15 business days.
