Product Detail
Product NameCollagen IV Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 1430-1480 1669 derived from mouse Collagen alpha-1(IV) chain
Target NameCollagen IV
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesBru; Raw; Svc; Col4a-1; Del(8)44H; Collagen alpha-1(IV) chain; Col4a1
Accession NoSwiss-Prot#P02463
NCBI Gene ID12826
Uniprot
P02463
Gene ID
12826;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=1:50-200 IF=1:50-200
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1 2 and p38 MAPK activation. Ligand for alpha1 beta1 integrin (By similarity).
If you have published an article using product C00452F, please notify us so that we can cite your literature.
15 business days.
