Product Detail
Product NameVE Cadherin Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt ICC IF
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 621-660 784 derived from mouse Vascular endolial cell cadherin
Target NameVE Cadherin
ConjugateFITC
Excitation Emission494nm 518nm
Other Names7B4; Vec; VECD; Cd144; VEcad; VE-Cad; AA48225; Cadherin-5; Vascular endothelial cadherin; VE-cadherin; Cdh5
Accession NoSwiss-Prot#P55284
NCBI Gene ID12562
Uniprot
P55284
Gene ID
12562;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
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15 business days.
