Product Detail
Product NameTransferrin receptor Antibody FITC Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsFlow-Cyt
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 620-670 760 derived from human Transferrin receptor
Target NameTransferrin receptor
ConjugateFITC
Excitation Emission494nm 518nm
Other NamesT9; TR; TFR; p90; CD71; TFR1; TRFR; Transferrin receptor protein 1; TFRC
Accession NoSwiss-Prot#P02786
NCBI Gene ID7037
Uniprot
P02786
Gene ID
7037;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
Flow-Cyt=2ug/Test
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
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15 business days.
