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Location： Home > Conjugated Antibodies > Factor I heavy chain Antibody HRP Conjugated

Factor I heavy chain Antibody HRP Conjugated#C00703H

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Product Detail

Product NameFactor I heavy chain Antibody HRP Conjugated

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationPurified by Protein A.

ApplicationsWB,,IHC-P,IHC-F,ICC

Species ReactivityHu Ms Rt

Immunogen DescKLH conjugated synthetic peptide derived from human Complement factor I heavy chain

Target NameFactor I heavy chain

ConjugateHRP

Excitation EmissionN A

Other NamesFactor I heavy chain; AHUS3; C3b INA; C3b inactivator; C3B C4B inactivator; C3BINA; CFAI_HUMAN; CFI; Complement component I; Complement control protein factor I; Complement factor I; Complement factor I heavy chain; F1; factor I; FactorI; FI; I factor; ; KAF; Konglutinogen activating factor; Heavy c

Concentration1mg ml

Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.

Application Details
WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
The complement pathway is an important host defense system that contributes to both innate and acquired immunity. There are three pathways of complement activation: the classical pathway, lectin pathway and alternative pathway. Complement protein Factor I is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. It circulates in plasma as a heavily N-glycosylated heterodimer made up of two disulfide linked chains, each carrying three N-linked oligosaccharide chains that may have both structural and functional roles in the interactions with the natural substrate and the cofactor during catalysis. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement proteins; Factor H, CR1 or MCP are required for C3b cleavage, and C4bp or CR1 are required for C4b cleavage.

If you have published an article using product C00703H, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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