Product Detail
Product NameHPV16-E7 Antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
Applications,IHC-P,IHC-F,ICC
Species ReactivityHu
Immunogen DescKLH conjugated synthetic peptide aa 50-98 98 derived from middle of HPV16-E7
Target NameHPV16-E7
ConjugateHRP
Excitation EmissionN A
Other NamesProtein E7; E7
Accession NoSwiss-Prot#P03129
NCBI Gene ID1489079
Uniprot
P03129
Gene ID
1489079;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.
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15 business days.
