Product Detail
                                
                                                                        Product Name5-HTR2 Antibody FITC Conjugated
                                                                                 Host SpeciesRabbit
                                         ClonalityPolyclonal
                                        IsotypeIgG
                                        PurificationPurified by Protein A.
                                        ApplicationsFlow-Cyt,IF
                                        Species ReactivityHu Ms Rt
                                                                                                                         Immunogen DescKLH conjugated synthetic peptide aa 80-130 471 derived from human 5-HTR2A
                                         Target Name5-HTR2
                                         ConjugateFITC
                                         Excitation Emission494nm 518nm
                                         Other NamesHTR2; 5-HT2A; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A; HTR2A
                                        Accession NoSwiss-Prot#P28223
NCBI Gene ID3356
                                        Uniprot
                                        P28223
                                        
                                        Gene ID
                                        3356;
                                        
                                                                                                                        Concentration1mg ml
                                         Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
                                        StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
                                                                                                                                                         
                                Application Details
                                Flow-Cyt=2ug/Test IF=1:50-200 
                             
                            
                                                            
                            
                                G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
                            
                            
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