Product Detail
Product NameDERLIN-1 Antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
Applications,IHC-P,IHC-F,ICC
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 120-170 251 derived from human DERLIN-1
Target NameDERLIN-1
ConjugateHRP
Excitation EmissionN A
Other NamesDerlin1; Derlin1; Derlin 1; DER1; DER-1; DER 1; DERL1_HUMAN.
Accession NoSwiss-Prot#Q9BUN8
NCBI Gene ID79139
Uniprot
Q9BUN8
Gene ID
79139;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
Degradation in endoplasmic reticulum proteins, also designated Derlins or DERtrins, are crucial for the degradation of misfolded endoplasmic reticulum (ER) luminal proteins. Derlin proteins are multi-pass membrane proteins localizing to the ER. Derlins are involved in transferring misfolded proteins from the ER to the cytosol, where the misfolded proteins are destroyed in an ubiquitin-dependent manner by the proteasome. In the case of cytomegalovirus infection, Derlin-1, as opposed to Derlins-2 and -3, is involved in the export of MHC class I heavy chains from the ER via its interaction with the viral protein US11. Derlins may also be important for cell proliferation.
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