Product Detail
Product NameRGMA Antibody HRP Conjugated
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationPurified by Protein A.
ApplicationsWB,,IHC-P,IHC-F,ICC
Species ReactivityHu Ms Rt
Immunogen DescKLH conjugated synthetic peptide aa 340-390 450 derived from human Repulsive Guidance Molecule A
Target NameRGMA
ConjugateHRP
Excitation EmissionN A
Other NamesRGM; Repulsive guidance molecule A; RGM domain family member A; RGMA
Accession NoSwiss-Prot#Q96B86
NCBI Gene ID56963
Uniprot
Q96B86
Gene ID
56963;
Concentration1mg ml
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageShipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.
Application Details
WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1 neogenin induces activation of RHOA-ROCK1 Rho-kinase signaling pathway through UNC5B-ARHGEF12 LARG-PTK2 FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1 neogenin leads to HRAS inactivation by influencing HRAS-PTK2 FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
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